MAIN ACHIEVEMENTS & SIGNIFICANT ACTIONS 2020-2024
FHU CARE Cancer and Autoimmunity Relationships
MAIN ACHIEVEMENTS & SIGNIFICANT ACTIONS 2020-2024
TNF SENESCENCE clinical trial (TNFSEN)
Aim: Investigate T cell senescence and exhaustion in autoimmune diseases.
Inclusion: 67 patients (25 RA, 22 SpA, 20 Sjögren's).
Findings: Higher senescence and exhaustion in autoimmune conditions.
One article under revision and one submitted.
Lead Researchers: Pr. Gaëtane Nocturne, Pr. Nathalie Chaput-Gras, Dr. Samuel Bitoun.
CITAR clinical trial (Checkpoint Inhibitors Treatment Arthritis)
Aim: Compare early IL-6R blockade (tocilizumab) vs. glucocorticoids for treating arthritis from cancer immunotherapy.
Participants: 112 patients, randomized, multicenter trial. Sponsored by Karolinska Institute.
Results: First trial center opened in Sweden in March 2024. 8 out of 106 patients included so far.
PI for France: Dr. Samuel Bitoun. Scientific Coordinator: Pr. Xavier Mariette.
PICASSO clinical trial
Goal: Evaluate fecal transplantation combined with immunotherapy on anti-cancer efficacy in metastatic melanoma patients.
Participants: 70 patients.
Status: Recruitment complete, results expected by end of 2024.
Lead: Pr. Franck Carbonnel, Patricia Lepage.
PREMIS study
Objective: Identify predictive biomarkers of immunological adverse events from immune checkpoint inhibitors.
Participants: 1,000 patients.
Results: Multiple publications and ongoing collaborations.
Leads: Pr. Aurélien Marabelle, Dr. François-Xavier Danlos.
SPOC MIRACIP Online Course
Content: Management of toxicities associated with anti-cancer immunotherapies.
Outcome: Over 200 registrations across 2 editions, with participants from 11 countries.
Coordinator: Pr. Olivier Lambotte.
iTox Symposium 2024
Purpose: Update on toxicities associated with anti-cancer immunotherapies, featuring international speakers, including Americans. Organized annually.
Date: May 22-23, 2024, at Bicêtre Faculty of Medicine, UPSaclay.
ONCOach Podcasts
Content: 13 episodes on immunotherapy toxicities, initiated by Dr. Audrey Perret.
Audience: Healthcare personnel.
Women in Sciences (WiS) Workshops
Events: 3 editions focusing on women's health and gender equality in healthcare, with 326 participants.
Next Edition: November 20, 2024, at Hôpital Européen Georges Pompidou.
European Guidelines for the Management of Immune-related Adverse Events (irAE)
Lead: Pr. Xavier Mariette led the development of guidelines for the diagnosis and management of rheumatic irAEs.
MAIN SUBMITTED PROJECTS
Funding Applications: FHU CARE has applied for over 50 projects, securing €2.2 million in funding.
DIM ITAC
The Paris region (Île-de-France) awarded Pr. Caroline Robert and Pr. Xavier Mariette a Major Interest Domain (DIM) on Immunotherapies, Auto-immunity, and Cancer with funding of €11 million for 5 years.
PUBLICATIONS
Total FHU CARE Publications (2021-2024): 135 entries. See the website under the Publications section.
COMMUNICATION AND OUTREACH
Newsletter: News2CARE sent monthly to over 300 contacts.
Social media: Active on LinkedIn and Twitter.
Events Organized: 6 General Assemblies, 1 Webinar, 3 Scientific Workshops.
