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Objectives
- Provide a comprehensive overview of CAR-T Cells, Bispecifics and Antibody-Drug Conjugates in Autoimmune Diseases
- Cover the full spectrum: from CAR-T fundamentals to advanced immunology mechanisms
- Develop practical skills for managing patients treated with Bispecific T-cell engagers
- Including CRS, ICANS and infection management
- Participate in interactive workshops to better understand the design and mechanisms of these molecules
Keynote & Lectures – invitations in progress
Michel Sadelain — Keynote Speaker
Affiliation: Memorial Sloan Kettering Cancer Center (MSKCC), New York, USA.
Specialty: CAR T‑cell engineering, gene-modified T cells, cellular immunotherapy.
Scientific contribution: Architect of modern CAR T‑cell design; his work established the foundations of engineered T‑cell therapies now used worldwide.
Georg Schett
Affiliation: Friedrich-Alexander University Erlangen-Nürnberg, Germany.
Specialty: Immunology of autoimmunity, cytokine pathways, immunomodulation.
Scientific contribution: Defined key inflammatory circuits in systemic autoimmune diseases and pioneered cytokine-targeted therapeutic strategies.
Aimee S. Payne
Affiliation: University of Pennsylvania, USA.
Specialty: Autoimmune blistering diseases, B‑cell targeting, precision immunology.
Scientific contribution: Leader in pemphigus research; advanced targeted immunotherapies and antigen-specific approaches.
Bernard Maillere
Affiliation: CEA / Université Paris-Saclay, France.
Specialty: Antigen presentation, T‑cell epitopes, immunogenicity prediction.
Scientific contribution: Major contributions to HLA–peptide interactions and CD4+ T‑cell activation mechanisms.
Xavier Mariette
Affiliation: Université Paris-Saclay / Inserm / Hôpital Bicêtre, France.
Specialty: Sjögren’s syndrome, systemic autoimmunity, clinical immunology.
Scientific contribution: Identified biomarkers and pathogenic pathways shaping modern therapeutic trials in Sjögren’s disease.
Melanie Hagen
Affiliation: University of Florida, USA.
Specialty: Autoimmune dermatology, inflammatory skin diseases.
Scientific contribution: Advances in understanding immune dysregulation in cutaneous autoimmunity and targeted dermatologic therapies.
Ricardo Gisabert Bouyet
Affiliation: European academic hospital
Specialty: Translational immunology and immune-mediated diseases.
Scientific contribution: Works on immune cell interactions and emerging therapeutic strategies in chronic inflammation.
Alexis Talbot
Affiliation: Immunology research centers in Europe
Specialty: Immune tolerance, clinical immunology, regulatory pathways.
Scientific contribution: Contributions to cellular and molecular mechanisms underlying tolerance in autoimmunity.
Julien Zuber
Affiliation: Hôpital Necker AP-HP / Université Paris Cité, France.
Specialty: Transplant immunology, alloimmunity, immune modulation.
Scientific contribution: Research on T‑cell responses and strategies to prevent graft rejection.
Mathieu Uzzan
Affiliation: AP‑HP / Université Paris Cité, France.
Specialty: Immunopathology, inflammatory biomarkers, clinical immunology.
Scientific contribution: Characterizes immune signatures and inflammatory pathways in systemic diseases.
Christina Castilla Laurente
Affiliation: European immunology institute
Specialty: Cellular immunology, effector mechanisms.
Scientific contribution: Studies immune cell interactions driving autoimmune responses.
Jeanne Gauthier
Affiliation: AP-HP, Inserm, Université Paris-Saclay IDMIT
Specialty: Immune signaling pathways, adaptive immunity.
Scientific contribution: Investigates molecular circuits shaping T‑ and B‑cell responses.
Samuel Bitoun
Affiliation:AP-HP / Inserm / Université Paris-Saclay
Specialty:Lymphocyte activation, cellular immunology.
Scientific contribution:Works on dysregulated immune activation in inflammatory diseases.
Laurie Menger
Affiliation: Institut Cochin / Université Paris Cité, France.
Specialty: Tissue immunology, microenvironmental regulation.
Scientific contribution: Explores local immune circuits shaping chronic inflammation.
Nathalie Chaput‑Gras
Affiliation: Institut Gustave Roussy, France.
Specialty: Dendritic cells, antigen presentation, adaptive immunity.
Scientific contribution: Advances understanding of dendritic cell biology and immune activation in cancer and autoimmunity.
Organization Committee
The Summer School is coordinated by a multidisciplinary committee of clinicians and scientists from leading French institutions in immunology, hematology, gastroenterology, and translational medicine:
- Prof. Xavier Mariette – Immuno‑rheumatologist and hematologist; Head of the Department of Immuno‑Rheumatology, Hôpital Bicêtre, Université Paris‑Saclay; Founder of FHU CARE and co-PI of DIM ITAC.
- Dr. Samuel Bitoun – Immuno‑rheumatologist and hematologist ; Coordinator of FHU CARE².
- Dr. Camille Bigenwald – Hematologist and immunology researcher, Institut Gustave Roussy.
- Prof. Mathieu Uzzan – Gastroenterologist and immunologist, Université Paris‑Est Créteil (UPEC).
- Dr. Laurie Menger – Cellular Immunotherapy Program, Institut Gustave Roussy.
- Dr. Léo Plaçais – Internal Medicine and immunologist, Hôpital Bicêtre, Université Paris‑Saclay; FHU CARE².
- Myriam Morcel – Project Manager FHU CARE².
PRELIMINARY PROGRAM – invitations in progress
| Speaker(s) | Duration | Time | |
| The Journey of B cell depletion in Rheumatology | Xavier Mariette | 30min | 17h00 – 17h30 |
| B cell depletion in IBD: the right target? | Mathieu Uzzan | 30min | 17h30 – 18h00 |
| Targeting plasma cells in kidney transplantation | Julien Zuber Alexis Talbot | 45min | 18h00 – 18h45 |
Social Dinner: 19h15
| Speaker(s) | Duration | Time | |
| Bispecific TCE in AID – Blina/ Teclistamab | Melanie Hagen | 20min | 09h00 – 09h20 |
| CAR-T cells in AID: where are we? | Georg Schett | 20min | 09h20 – 09h40 |
| Antigen specific CAR-T cell | Aimee S Payne | 50min | 09h40 – 10h30 |
Coffee break : 10h30-11h00
| B cell reset the way to AID cure? | Ricardo Gisabert Bouyet | 30min | 11h00 – 11h30 |
| Debate: Bispecifics and CAR-T which is the best tool | Georg Schett Alexis Talbot | 1h | 11h30 – 12h30 |
Launch : 12h30-14h00
| Managing CAR‑T and Bispecific Toxicities: Clinical Cases on Cytopenias, Atypical Infections, and Prophylaxis | Christina Castilla Laurente | 1h | 14h00 – 15h00 |
| Debate: CD19/BCMA the best target? | Jeanne Gauthier Ricardo Gisabert Bouyet | 1h | 15h00 – 16h00 |
Coffee break : 16h00-16h30
| CAR-T cells in animal models of autoimmune diseases | Samuel Bitoun | 30mn | 16h30 – 17h00 |
| Antibody drug conjugates | Bernard Maillere | 30mn | 17h00 – 17h30 |
Mountain Walk: 17h00-19h00
Social Dinner: 20h00
| Speaker(s) | Duration | Time | |
| Allogenic CAR-T cells Challenges in AID | Laurie Menger | 30min | 09h00 – 09h30 |
| Next generation CAR-T cell how could they improve AID? | Michel Sadelain | 1h | 09h30 – 10h30 |
Coffee Break: 10h30-11h00
Workshop: 11h00 – 12h00
Design your CAR-T for AID
Michel Sadelain
Aimee Payne / Alexis Talbot
Design your Bispecific for AID
Bernard Maillere
Others
Restitution: 12h00-13h00
Lunch: 13h00-14h00
| T cells in TCE Bispecifics (optional) | Nathalie Chaput-Gras | 30min | 14h00 – 14h30 |
Attendees
The Summer School is open to physicians and scientists from various specialties, including:
- Rheumatologists
- Internal Medicine specialists
- Haematologists
- Nephrologists
- Gastroenterologists
- Neurologists
- Postdoctoral researchers and Laboratory PIs
Location : Les Pensières
- 40 minutes from Geneva Airport
- 10 minutes from Annecy train station
- Acces & Plan
Sponsors – under progress
Application Process
Send your application before March 26, 2027, including:
- CV, letter of motivation and letter of recommendation from a professor and/or research supervisor.
- Applications will be evaluated by the organization committee on the basis of the above documents.
- Send your application to : myriam(dot)morcel(at)aphp(dot)fr