{"id":17,"date":"2025-11-19T23:36:58","date_gmt":"2025-11-19T22:36:58","guid":{"rendered":"https:\/\/fhucare.com\/axis-3-new-treatments\/"},"modified":"2026-04-16T12:16:09","modified_gmt":"2026-04-16T10:16:09","slug":"new-treatments","status":"publish","type":"page","link":"https:\/\/fhucare.com\/fr\/research-axes\/new-treatments\/","title":{"rendered":"New Treatments &#8211; TREAT\u00a0"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<h2 class=\"wp-block-heading has-large-font-size\" style=\"margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0;line-height:1\"><em><strong>Leaders<\/strong><\/em><\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-global-padding is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-7e55dad3 wp-block-column-is-layout-constrained\" style=\"flex-basis:90%\">\n<div class=\"wp-block-group is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-c762a482 wp-block-group-is-layout-flex\" style=\"margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0\">\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Xavier-Mariette\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"270\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2025\/12\/Pr_Xavier-Mariette_portrait.webp\" alt=\"\" class=\"wp-image-598\"\/><\/a><figcaption class=\"wp-element-caption\"><strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Xavier-Mariette\">Xavier Mariette<\/a><\/strong><\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"270\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2025\/12\/Dr_Samuel-Bitoun_portrait.webp\" alt=\"\" class=\"wp-image-615\"\/><\/a><figcaption class=\"wp-element-caption\"><strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\">Samuel Bitoun<\/a><\/strong><\/figcaption><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-grey-to-white-gradient-background has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<p class=\"has-large-font-size\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);line-height:1\"><em><strong>Task 1<\/strong><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:90%\">\n<h3 class=\"wp-block-heading\"><em><strong>To set-up randomized controlled trials of immunosuppressive biologic drugs in immune related adverse events post immune check-points<\/strong><\/em><\/h3>\n\n\n\n<p><strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\">Samuel Bitoun<\/a><\/strong> is the French PI of a <strong>multicentric European<\/strong> <strong>prospective trial<\/strong> called <strong>CITAR<\/strong>.<\/p>\n\n\n\n<p>This innovative randomized controlled clinical trial compares for the first time <strong>corticosteroids <\/strong>and <strong>tocilizumab<\/strong> (anti- IL-6R) in rheumatologic Immune-Related Adverse Events induced by ICI. <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Ariane-Laparra\" target=\"_blank\" rel=\"noreferrer noopener\">Arianne Laparra<\/a><\/strong> (Gustave Roussy) participates by referring patients. CITAR is coordinated by <strong>Karolinska Institutet<\/strong> and <strong>5 French centers <\/strong>participated in the CITAR clinical trial.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-align-center wp-element-button\" href=\"https:\/\/fhucare.com\/clinical-trials\/citar\/\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\" target=\"_blank\" rel=\"noreferrer noopener\">Read more about CITAR Trial<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:35% auto\"><figure class=\"wp-block-media-text__media\"><a href=\"https:\/\/fhucare.com\/clinical-trials\/citar\/\" target=\"_blank\" rel=\" noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"186\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Logo_CITAR.webp\" alt=\"\" class=\"wp-image-3005 size-full\"\/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<p>Watch the presentation of the CITAR Clinical Trial led by <strong><strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\">Samuel Bitoun<\/a><\/strong><\/strong>, scientific coordinator FHU CARE\u00b2:<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"CITAR : TOCI vs CORTICO - Itox Dr Samuel Bitoun - CITAR (Checkpoint Inhibitors Treatment Arthritis)\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/LIQzdXq6eGc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-grey-to-white-gradient-background has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<p class=\"has-large-font-size\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);line-height:1\"><em><strong>Task 2<\/strong><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:90%\">\n<h3 class=\"wp-block-heading\"><em><strong>To encourage randomized controlled trials with association of immunosuppressive biologic drugs and immune checkpoint in cancer to improve anti-cancer efficacy<\/strong><\/em><\/h3>\n\n\n\n<p>FHU CARE\u00b2 favor opening centers among members of the project in international trials testing the anticancer efficacy of adding immunomodulators to Immune Checkpoint Inhibitors. Recent evidence has shown the efficacy of combining JAKi and Immune Checkpoint Inhibitors&nbsp;in <strong>lung cancer<\/strong> (<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adf1329\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Mathew et al Science 2024<\/a>) and <strong>Hodgkin\u2019s lymphoma<\/strong> (<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ade8520\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Zaket al Science 2024<\/a>).<\/p>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-bea02a06 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:23% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"312\" height=\"312\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Caroline_Robert_Portrait.webp\" alt=\"\" class=\"wp-image-3019 size-full\" srcset=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Caroline_Robert_Portrait.webp 312w, https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Caroline_Robert_Portrait-150x150.webp 150w\" sizes=\"auto, (max-width: 312px) 100vw, 312px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"inlined-left-image\">A trial adding sarilumab (IL-6R inhibitor) to Immune Checkpoint Inhibitors in <strong>melanoma<\/strong> is actively recruiting (<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05428007\">NCT05428007<\/a>). <a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Caroline-Robert\"><strong>Caroline<\/strong> <strong>Robert<\/strong><\/a> is a candidate for this trial promoted by the <strong>MD Anderson Cancer center<\/strong> (Texas US).<\/p>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-7a9066b1 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"129\" height=\"80\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2025\/12\/logo_partenaire_Gustave_Roussy_80.webp\" alt=\"\" class=\"wp-image-2585\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"247\" height=\"83\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Logo_University-of-Texas.png\" alt=\"\" class=\"wp-image-3014\"\/><\/figure>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-grey-to-white-gradient-background has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-346627ba wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<p class=\"has-large-font-size\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);line-height:1\"><em><strong>Task 3<\/strong><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:90%\">\n<h3 class=\"wp-block-heading\"><em><strong>To evaluate new treatment strategies based on innovative B-cell targeted therapies (BTK inhibitors, new generation anti-CD20) in lymphomas complicating <\/strong><\/em><strong><em>autoimmune diseases<\/em><\/strong><\/h3>\n\n\n\n<p><strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Ga\u00ebtane-Nocturne\">Ga\u00ebtane Nocturne<\/a><\/strong> is a leading expert on the field of Sj\u00f6gren-associated lymphoma and initiates trials to test new drugs in lymphomas complicating <strong>autoimmune diseases<\/strong> and to assess their impact on Sj\u00f6gren\u2019s disease activity. <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Ga\u00ebtane-Nocturne\">Ga\u00ebtane Nocturne<\/a><\/strong> recently demonstrated that a systemic treatment strategy for Sj\u00f6gren\u2019s disease-associated lymphoma, rather than local treatment or watch and wait strategy, reduces the new Sj\u00f6gren\u2019s disease systemic activity risk (<strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39182508\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Rocca et al, Lancet Rheumatol 2024<\/a><\/strong>). Futures studies will evaluate the effect of innovative B-cell targeted therapies on lymphoma risk and assess the effect of new lymphoma treatment modalities on autoimmune diseases activity.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69e16697c2cd6&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69e16697c2cd6\" class=\"wp-block-image size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1223\" height=\"551\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/illustration_Research-Axes_Axe3_Task3.webp\" alt=\"\" class=\"wp-image-3020\" srcset=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/illustration_Research-Axes_Axe3_Task3.webp 1223w, https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/illustration_Research-Axes_Axe3_Task3-500x225.webp 500w, https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/illustration_Research-Axes_Axe3_Task3-768x346.webp 768w\" sizes=\"auto, (max-width: 1223px) 100vw, 1223px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Agrandir\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-grey-to-white-gradient-background has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<p class=\"has-large-font-size\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);line-height:1\"><em><strong>Task 4<\/strong><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:90%\">\n<h3 class=\"wp-block-heading\"><em><strong>To develop in collaboration with industry master protocols for evaluating anti-CD19 CAR-T<\/strong><\/em> <em><strong>cells,<\/strong><\/em> <em><strong>anti-CD3\/CD19<\/strong><\/em> <em><strong>bispecific<\/strong><\/em> <em><strong>antibodies,<\/strong> <\/em><em><strong>anti-CD19<\/strong><\/em> <em><strong>antibodies<\/strong><\/em> <em><strong>in<\/strong><\/em> <em><strong>patients<\/strong><\/em> <em><strong>with<\/strong><\/em> <em><strong>autoimmune diseases<\/strong><\/em><\/h3>\n\n\n\n<p><strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Xavier-Mariette\">Xavier Mariette<\/a><\/strong> with others recently created a multidisciplinary national group called <strong>Innovative<\/strong> <strong>Immunomodulatory<\/strong> <strong>drugs<\/strong> <strong>in<\/strong> <strong>IMIDs<\/strong> (<a href=\"https:\/\/www.linkedin.com\/in\/club-des-immunoth%C3%A9rapies-innovantes-dans-les-imids-c3i-a447b334a\/\" data-type=\"link\" data-id=\"https:\/\/www.linkedin.com\/in\/club-des-immunoth%C3%A9rapies-innovantes-dans-les-imids-c3i-a447b334a\/\">Club C3i<\/a>), on the umbrella of the national network on rare <strong>systemic autoimmune diseases<\/strong> (<a href=\"https:\/\/www.fai2r.org\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">FAI2R<\/a>). This group aims favoring all initiatives <strong>for developing innovative immunotherapies in autoimmune diseases<\/strong> and especially discussions <strong>with industry <\/strong>partners for developing master basket trials for evaluating their <strong>new drugs in patients with severe autoimmune diseases<\/strong>.<\/p>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-877c468d wp-block-group-is-layout-flex\">\n\n<\/div>\n\n\n\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-335b1c95 wp-block-group-is-layout-flex\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-081cea82 wp-block-group-is-layout-constrained\"><\/div>\n\n\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-59e203da wp-block-columns-is-layout-flex\" style=\"padding-right:0;padding-left:0\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:45%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:55%\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-grey-to-white-gradient-background has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<p class=\"has-large-font-size\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);line-height:1\"><em><strong>Task 5<\/strong><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:90%\">\n<h3 class=\"wp-block-heading\"><em><strong>To develop and preclinically test bispecific T-cell engager (BiTE) antibody and Chimeric autoantibody T-cells (CAAR-T cells) targeting the autoimmune B cells specifically.<\/strong><\/em><\/h3>\n\n\n\n<p>With the expertise of <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Xavier-Mariette\">Xavier Mariette<\/a><\/strong>, <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\">Samuel Bitoun<\/a><\/strong>, <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Rapha\u00e8le-Seror\">Rapha\u00e8le Seror<\/a><\/strong> and <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Ga\u00ebtane-Nocturne\">Ga\u00ebtane Nocturne<\/a><\/strong> (IDMIT UMR1184 \/IMVA-HB) in Sj\u00f6gren\u2019s disease and the expertise of <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Bernard-Maillere\">Bernard Maillere<\/a><\/strong> (CEA, Cellular Immunology and Biotechnology lab) in antibody engineering , new bispecific antibodies are being developped targetting CD3 and SSA. With the expertise of <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Camille-Bigenwald\">Camille Bigenwald<\/a><\/strong> and <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#St\u00e9phane-De-Botton\">St\u00e9phane de Botton<\/a> <\/strong>(Hematology, Gustave Roussy) we will develop and produce SSA\/ RF CAAR-T cells and test them in <em>in vivo<\/em> Sj\u00f6gren disease models.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:200px\">\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"291\" height=\"383\" data-id=\"3854\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/JeanneGauthier2026.jpg\" alt=\"\" class=\"wp-image-3854\"\/><figcaption class=\"wp-element-caption\"><br><strong>Jeanne Gauthier, PhD <\/strong><\/figcaption><\/figure>\n<\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-grey-to-white-gradient-background has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<p class=\"has-large-font-size\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);line-height:1\"><em><strong>Task 6<\/strong><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:90%\">\n<h3 class=\"wp-block-heading\"><em><strong>To develop and preclinically test new CAR-T cell targets like CD30 and ROR1 in hematological and solid malignancies<\/strong><\/em><\/h3>\n\n\n\n<p>A fully immunocompetent mouse model of CD19 CAR-T cells has been implemented by <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Camille-Bigenwald\">Camille Bigenwald<\/a> <\/strong>(Hematology, Gustave Roussy). They demonstrated that the resistance to CD19 CAR-T cells is caused by defects in CAR-T cells occurring early or because of specific changes in the cancer immune environment, rather than by the loss of antigen expression or defects in CAR-T cell persistence. Therefore, using our relevant mouse model, <strong>combination therapies<\/strong> aimed at <strong>improving<\/strong> <strong>the<\/strong> <strong>effectiveness<\/strong> <strong>of<\/strong> <strong>CAR-T<\/strong> <strong>cells<\/strong> <strong>aretested<\/strong> <strong>with<\/strong> <strong>CD19<\/strong> <strong>CAR-T<\/strong> <strong>cells<\/strong> but also with <strong>other settings such as CD30 CAR-T cells<\/strong> and <strong>ROR1 CAR-T cells<\/strong>. These approaches are interesting given the limited results in clinical trials for Hodgkin lymphoma and solid tumors.<\/p>\n\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-custom-grey-to-white-gradient-background has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100px\">\n<p class=\"has-large-font-size\" style=\"margin-top:var(--wp--preset--spacing--40);margin-bottom:var(--wp--preset--spacing--40);line-height:1\"><em><strong>Task 7<\/strong><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:90%\">\n<h3 class=\"wp-block-heading\"><em><strong>To set-up a platform of intensive immunotherapy in autoimmune diseases and haematology in Bic\u00eatre hospital and Institut Gustave Roussy. This allows to test CD19 CART-T cells and CAR-T cells<\/strong><\/em><\/h3>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\" style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0;grid-template-columns:auto 51%\"><div class=\"wp-block-media-text__content\">\n<p class=\"has-text-align-right\"><strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Camille-Bigenwald\">Camille Bigenwald<\/a><\/strong> has obtained from <strong>Institut Gustave Roussy<\/strong> to invest in the <strong>local production of human<\/strong> <strong>CAR-T<\/strong> and <strong>CAAR-T cells<\/strong> with the acquisition of a <strong>Miltenyi Prodigy machine<\/strong>. <br>The machine was used by M\u00fcller et al (<strong>NEJM 2023<\/strong>) leading to the <strong>proof of concept of CD19 CAR-T cells efficacy in lupus patients<\/strong>.<br>This is allowed to produce CD19 CAR-T cells for unapproved indications like refractory autoimmune diseases (<strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\">Samuel Bitoun<\/a><\/strong> and <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Xavier-Mariette\">Xavier Mariette<\/a><\/strong>), and refractory pediatric lymphomas.<br> This paves the way for innovative CAR-T cell approaches such as CAAR-T and BiTEs.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><a href=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Miltenyi-Prodigy_Machine_cMiltenyi_Biotec.webp\"><img loading=\"lazy\" decoding=\"async\" width=\"815\" height=\"960\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Miltenyi-Prodigy_Machine_cMiltenyi_Biotec.webp\" alt=\"\" class=\"wp-image-3026 size-full\" srcset=\"https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Miltenyi-Prodigy_Machine_cMiltenyi_Biotec.webp 815w, https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Miltenyi-Prodigy_Machine_cMiltenyi_Biotec-424x500.webp 424w, https:\/\/fhucare.com\/wp-content\/uploads\/2026\/01\/Miltenyi-Prodigy_Machine_cMiltenyi_Biotec-768x905.webp 768w\" sizes=\"auto, (max-width: 815px) 100vw, 815px\" \/><\/a><\/figure><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Leaders Task 1 To set-up randomized controlled trials of immunosuppressive biologic drugs in immune related adverse events post immune check-points Samuel Bitoun is the French PI of a multicentric European prospective trial called CITAR. This innovative randomized controlled clinical trial compares for the first time corticosteroids and tocilizumab (anti- IL-6R) in rheumatologic Immune-Related Adverse Events [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":14,"menu_order":30,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Treatments - TREAT\u00a0 - FHU CARE\u00b2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhucare.com\/fr\/research-axes\/new-treatments\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Treatments - TREAT\u00a0 - FHU CARE\u00b2\" \/>\n<meta property=\"og:description\" content=\"Leaders Task 1 To set-up randomized controlled trials of immunosuppressive biologic drugs in immune related adverse events post immune check-points Samuel Bitoun is the French PI of a multicentric European prospective trial called CITAR. 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