{"id":14,"date":"2025-11-19T23:36:56","date_gmt":"2025-11-19T22:36:56","guid":{"rendered":"https:\/\/fhucare.com\/axis-wps\/"},"modified":"2026-03-05T17:19:49","modified_gmt":"2026-03-05T16:19:49","slug":"research-axes","status":"publish","type":"page","link":"https:\/\/fhucare.com\/fr\/research-axes\/","title":{"rendered":"Research Axes"},"content":{"rendered":"\n<p>Building on the achievements of <strong>FHU CARE<\/strong> (2020\u20132024), the <strong>FHU CARE\u00b2<\/strong> (2025-2030) project brings together leading clinicians and scientists from <strong>AP-HP Bic\u00eatre<\/strong>, <strong>Universit\u00e9 Paris-Saclay<\/strong>, and <strong>Institut Gustave Roussy<\/strong> to accelerate <strong>innovations in autoimmunity<\/strong>, <strong>cancer<\/strong>, <strong>and immunotherapies<\/strong>.<\/p>\n\n\n\n<p>The ambition: to develop <strong>new predictive tools<\/strong>,<strong> decipher key mechanisms linking autoimmunity and cancer<\/strong>, <strong>and design advanced therapeutic strategies<\/strong> with the ultimate goal of <strong>curing autoimmune diseases<\/strong>.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p style=\"margin-top:var(--wp--preset--spacing--30)\">The project is structured around <strong>four interconnected Axes <\/strong>:<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-1-color\">INNOVATE<\/mark><\/em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-4-color\"> <\/mark>\u2014 Innovative Experimental Models &amp; Predictive Tools<\/strong> (Axis 1)<\/h2>\n\n\n\n<p>Leaders : <a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Ga%C3%ABtane-Nocturne\"><strong>Ga\u00ebtane<\/strong> <strong>Nocturne<\/strong><\/a> &amp; <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Rapha\u00e8le-Seror\">Rapha\u00e8le Seror<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Development of <strong>patient-derived immuno-organoids<\/strong> to model autoimmune diseases, inspired by cancer organoid technologies.<\/li>\n\n\n\n<li>Integration of <strong>large-scale health data<\/strong> (<a href=\"https:\/\/eds.aphp.fr\/\" data-type=\"link\" data-id=\"https:\/\/eds.aphp.fr\/\">EDS<\/a>, <a href=\"https:\/\/www.snds.gouv.fr\/SNDS\/Accueil\" data-type=\"link\" data-id=\"https:\/\/www.snds.gouv.fr\/SNDS\/Accueil\">SNDS<\/a>) and <strong>artificial intelligence<\/strong> (AI) to evaluate cancer risk across autoimmune diseases and therapeutic contexts.<\/li>\n\n\n\n<li>Application of <strong>AI-based image analysis<\/strong> to identify diagnostic and prognostic markers in patient biopsies.<\/li>\n\n\n\n<li>Implementation of <strong>computational systems biology<\/strong> approaches to predict lymphomagenesis in Sj\u00f6gren\u2019s syndrome.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe1bbffc wp-block-buttons-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/fhucare.com\/research-axes\/new-tools\/\">Read about <strong>Innovative Experimental Models &amp; Predictive tools<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-1-color\">UNDERSTAND<\/mark><\/em> \u2014 Mechanisms Linking Autoimmunity and Cancer<\/strong> (Axis 2)<\/h2>\n\n\n\n<p>Leader : <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Camille-Bigenwald\">Camille Bigenwald<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Investigation of the impact of <strong>JAK inhibitors<\/strong> and other <strong>targeted anti-inflammatory biologics<\/strong> on cancer immune surveillance.<\/li>\n\n\n\n<li>Deciphering the <strong>molecular transition from autoimmunity to lymphomagenesis<\/strong>, particularly in <strong>Sj\u00f6gren\u2019s syndrome<\/strong>.<\/li>\n\n\n\n<li>Comparative studies of <strong>immunomodulators<\/strong> used for <strong>immune-related adverse events (irAEs)<\/strong> following immune checkpoint inhibitor therapies.<\/li>\n\n\n\n<li>Identification of mechanisms driving both <strong>therapeutic efficacy and toxicity<\/strong> of <strong>CAR-T cells<\/strong> and <strong>bispecific T-cell engagers (BiTEs)<\/strong> in cancer and autoimmunity.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe1bbffc wp-block-buttons-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/fhucare.com\/research-axes\/new-mechanisms\/\">Read about <strong>Mechanisms Linking Autoimmunity and Cancer<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-1-color\">TREAT<\/mark><\/em> \u2014 Advanced Therapeutic Strategies<\/strong> (Axis 3)<\/h2>\n\n\n\n<p>Leaders: <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Xavier-Mariette\">Xavier Mariette<\/a> <\/strong>&amp; <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\">Samuel Bitoun<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Launch of <strong>randomized controlled trials<\/strong> assessing immunosuppressive biologics in <strong>immune-related adverse events<\/strong> post immune checkpoint inhibitors.<\/li>\n\n\n\n<li>Development of <strong>combination trials<\/strong> associating <strong>immunosuppressive biologics<\/strong> and <strong>immune checkpoint therapies<\/strong> to enhance anti-cancer efficacy.<\/li>\n\n\n\n<li>Evaluation of <strong>innovative B-cell\u2013targeted therapies<\/strong> (BTK inhibitors, next-generation anti-CD20) in lymphomas secondary to autoimmune diseases.<\/li>\n\n\n\n<li>Design of <strong>master protocols<\/strong> in partnership with industry to assess <strong>CAR-T cells<\/strong>, <strong>CAAR-T cells<\/strong>, and <strong>bispecific antibodies<\/strong> in autoimmune and hematologic diseases.<\/li>\n\n\n\n<li>Preclinical development of <strong>novel CAR-T targets<\/strong>, including <strong>CD130<\/strong>, for hematologic malignancies.<\/li>\n\n\n\n<li>Establishment of an <strong>Intensive Immunotherapy Platform<\/strong> at <strong>AP-HP Bic\u00eatre Hospital<\/strong> and <strong>Institut Gustave Roussy<\/strong>, dedicated to translational and clinical testing of advanced cellular therapies.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe1bbffc wp-block-buttons-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/fhucare.com\/research-axes\/new-treatments\/\">Read about <strong><strong>Advanced Therapeutic Strategies<\/strong><\/strong><\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-1-color\"><em>TEACH<\/em> <\/mark>\u2014 Education, Training &amp; Knowledge<\/strong> (Axis 4)<\/h2>\n\n\n\n<p>Leaders: <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Samuel-Bitoun\">Samuel Bitoun<\/a> <\/strong>&amp; <strong><a href=\"https:\/\/fhucare.com\/fhu-care2\/experts-and-network\/#Olivier-Lambotte\">Olivier Lambotte<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-2-color\"> <a href=\"https:\/\/fhucare.com\/journal-club-tijc\/\" data-type=\"link\" data-id=\"https:\/\/fhucare.com\/journal-club-tijc\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Transdisciplinary Immunology Journal Club<\/strong><\/a><\/mark><a href=\"https:\/\/fhucare.com\/journal-club-tijc\/\" data-type=\"link\" data-id=\"https:\/\/fhucare.com\/journal-club-tijc\/\" target=\"_blank\" rel=\"noreferrer noopener\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-4-color\"><strong> <\/strong><\/mark><\/a><strong>(TIJC)<\/strong> gathers clinicians, researchers, and students to discuss cutting-edge advances in <strong>immunopathology<\/strong>, with open access to replay sessions on <strong><a href=\"https:\/\/www.youtube.com\/@fhucare\/videos\" data-type=\"link\" data-id=\"https:\/\/www.youtube.com\/@fhucare\/videos\">YouTube<\/a><\/strong>. The Club TIJC is open to all immunology enthusiasts. It is a club that brings<strong>together autoimmunity and cancer<\/strong> : two worlds linked by one bridge.<\/li>\n\n\n\n<li>An <strong><a href=\"https:\/\/fhucare.com\/event\/first-international-summer-school-on-car-t-and-bispecifics-in-autoimmune-diseases\/\" data-type=\"link\" data-id=\"https:\/\/fhucare.com\/event\/first-international-summer-school-on-car-t-and-bispecifics-in-autoimmune-diseases\/\" target=\"_blank\" rel=\"noreferrer noopener\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-2-color\">annual International Summer School<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-4-color\"> <\/mark><\/strong>on <strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-2-color\">CAR-T<\/mark><\/strong>, <strong>CAAR-T<\/strong>, and <strong>BiTE <\/strong>management across <strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-contrast-color\">autoimmune<\/mark><\/strong> and <strong>oncologic<\/strong> settings.<\/li>\n\n\n\n<li>Expansion of <strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-2-color\">digital innovative learning platforms<\/mark> (<a href=\"https:\/\/www.medecine.universite-paris-saclay.fr\/formations\/formation-continue\/spoc-miracip-management-immunorelated-complication-cancer-immunotherapy\" data-type=\"link\" data-id=\"https:\/\/www.medecine.universite-paris-saclay.fr\/formations\/formation-continue\/spoc-miracip-management-immunorelated-complication-cancer-immunotherapy\">SPOC MIRACIP<\/a>)<\/strong> exploring the interface between <strong>autoimmunity<\/strong>, <strong>cancer<\/strong> and <strong>immune-checkpoint toxicities<\/strong>. Courses are designed for clinicians, scientists, and industrial partners.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe1bbffc wp-block-buttons-is-layout-flex\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30)\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/fhucare.com\/research-axes\/new-education\/\">Read about <strong><strong><strong>Education, Training &amp; Knowledge<\/strong><\/strong><\/strong><\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-1-color\">A Federative Ambition<\/mark><\/strong><\/h2>\n\n\n\n<p>FHU CARE\u00b2 embodies the hospital-university excellence of <strong>Universit\u00e9 Paris-Saclay<\/strong>, <strong>AP-HP<\/strong>, <strong>INSERM<\/strong>, and <strong>Gustave Roussy<\/strong> fostering <strong>transdisciplinary research<\/strong>, <strong>education<\/strong>, and <strong>clinical innovation<\/strong> at the frontiers of <strong>immunology <\/strong>and <strong>oncology<\/strong>.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69e166af67c33&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69e166af67c33\" class=\"wp-block-image size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"980\" height=\"436\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/fhucare.com\/wp-content\/uploads\/2025\/12\/mappingFHUCARE2.jpeg\" alt=\"\" class=\"wp-image-2489\" srcset=\"https:\/\/fhucare.com\/wp-content\/uploads\/2025\/12\/mappingFHUCARE2.jpeg 980w, https:\/\/fhucare.com\/wp-content\/uploads\/2025\/12\/mappingFHUCARE2-500x222.jpeg 500w, https:\/\/fhucare.com\/wp-content\/uploads\/2025\/12\/mappingFHUCARE2-768x342.jpeg 768w\" sizes=\"auto, (max-width: 980px) 100vw, 980px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Agrandir\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Building on the achievements of FHU CARE (2020\u20132024), the FHU CARE\u00b2 (2025-2030) project brings together leading clinicians and scientists from AP-HP Bic\u00eatre, Universit\u00e9 Paris-Saclay, and Institut Gustave Roussy to accelerate innovations in autoimmunity, cancer, and immunotherapies. The ambition: to develop new predictive tools, decipher key mechanisms linking autoimmunity and cancer, and design advanced therapeutic strategies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research Axes - FHU CARE\u00b2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhucare.com\/fr\/research-axes\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Axes - FHU CARE\u00b2\" \/>\n<meta property=\"og:description\" content=\"Building on the achievements of FHU CARE (2020\u20132024), the FHU CARE\u00b2 (2025-2030) project brings together leading clinicians and scientists from AP-HP Bic\u00eatre, Universit\u00e9 Paris-Saclay, and Institut Gustave Roussy to accelerate innovations in autoimmunity, cancer, and immunotherapies. 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